Biomimetic folding of small organic molecules driven by multiple non-covalent interactions
Literature Information
Tangxin Xiao, Lixiang Xu, Jie Wang, Zheng-Yi Li, Xiao-Qiang Sun
Here we report our research on biomimetic folding architectures self-assembled hierarchically from well-designed UPy-based monomers with low molecular weight (MW < 400 Da). These monomers are first dimerized via quadruple hydrogen bonding and then form folded dimers with the assistance of π–π interactions. More interestingly, the folded dimer further formed one-dimensional supramolecular stacks through additional weak π–π interactions in the solid state. Similar to DNA, these well-defined structures are stabilized by the concerted hydrogen bonding and π–π interaction in a synergistic manner, which would provide inspiration for constructing biomimetic self-folding materials.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry














