Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light
Literature Information
Publication Date
2019-09-30
DOI
10.1039/C9QO00935C
Impact Factor
5.281
Authors
Jiu-Jian Ji, Li-Jin Xiao, Dong Guo, Xiao Zhu, Juan Tang, Jun Wu, Zong-Bo Xie
View Original
Abstract
A novel, green and efficient visible-light-promoted decarboxylative aminoalkylation reaction of imidazo[1,2-a]pyridines with N-aryl glycines has been described. A diverse range of imidazo[1,2-a]pyridines undergoes the reaction well with N-aryl glycines to afford the desired corresponding products in good to high yields. This photocatalyst-free decarboxylative protocol not only manifests high regio-selectivity to biologically important imidazo[1,2-a]pyridines, but also avoids the use of expensive photosensitizers and extra additives, which makes this decarboxylative coupling more practical and sustainable.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(S)-1-(3-(Benzyloxy)phenyl)-3-(dimethylamino)-2-methylpropan-1-one (2r,3r)-2,3-bis(benzoyloxy)succinate
CAS Number:
1004315-81-4
Molecular Formula:
C37H37NO10
![3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile structure](https://static.chemtradehub.com/structs/164/1640971-60-3-83a4.webp "3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile structure")
3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)-methyl-amino]-4-methyl-1-piperidyl]-3-oxo-propanenitrile
CAS Number:
1640971-60-3
Molecular Formula:
C14H20N6O
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