Creation of bispiro[pyrazolone-3,3′-oxindoles] via a phosphine-catalyzed enantioselective [3 + 2] annulation of the Morita–Baylis–Hillman carbonates with pyrazoloneyldiene oxindoles

Literature Information

Publication Date 2019-05-06
DOI 10.1039/C9QO00471H
Impact Factor 5.281
Authors

Wai-Lun Chan, Ligong Chen, Nisar Ullah


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Abstract

A [3 + 2] annulation between the Morita–Baylis–Hillman (MBH) carbonates and pyrazoloneyldiene oxindoles catalyzed by (S)-SITCP has been developed. Structurally novel bispiro[pyrazolone-3,3′-oxindoles] containing two contiguous quaternary stereogenic centers were created in excellent yields, in a diastereospecific and highly enantioselective manner.

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Contents

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DOI: 10.1039/B508086J

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