Pacritinib | CAS No. 937272-79-2

Pacritinib

Basic Information

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CAS Number

937272-79-2

Molecular Formula

C28H32N4O3

Molecular Weight

472.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

694.3±65.0°C at 760 mmHg

Density

1.22±0.1 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (2.3E-3 g/L) (25 ºC),

SMILES

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C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC(=CC=C4)C5=NC(=NC=C5)NC(=C3)C=C2

InChI

InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+

InChIKey

HWXVIOGONBBTBY-ONEGZZNKSA-N

LogP

4.964800000000004

Topological Polar Surface Area

68.74000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

644

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

Synonyms & References

English

Pacritinib
(16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1<sup>2,6</sup>.1<sup>8,12</sup>]heptacosa-1(25),2(27),3,5,8(26),9,11,16,21,23-decaene
Pacritinib (SB1518)
Pacritinib
SB1518
SB-1518
(16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene
Pacritinib(SB1518)
G22N65IL3O
SB 1518
SB1518(Pacritinib)
Pacritinib [USAN:INN]
GTPL7793
AOB87797
BDBM50400312
NCGC00381564-02
SW219864-1
EX-A240
BRD-K19034817-001-01-4
NCGC00381564-09
AS-35036
UNII-G22N65IL3O
ONX 0803
NSC781626
(16E)-11-[2-(pyrrolidin-1-yl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(27),3,5,8(26),9,11,16,21,23-decaene
CHEBI:231350
937272-79-2
PACRITINIB [USAN]
AC-30280
s8057
CCG-269464

MDL Number

MFCD22572772

FAQ

What is Pacritinib (CAS: 937272-79-2)?

Pacritinib is a small molecule tyrosine kinase inhibitor. Its chemical formula is C26H21N5O4. This compound is used primarily for the treatment of myelofibrosis, a disorder that causes the bone marrow to produce excessive fibrous tissue and blood cells. It is also being studied for other hematological malignancies.

What are the main uses of Pacritinib (CAS: 937272-79-2)?

Pacritinib is mainly used for the treatment of myelofibrosis, a condition characterized by the build-up of scar tissue in the bone marrow. It is also being investigated for potential use in other hematological malignancies, such as acute myeloid leukemia. Its use can improve symptoms and quality of life in patients with myelofibrosis.

Is Pacritinib (CAS: 937272-79-2) safe?

Pacritinib is generally safe when used under medical supervision. However, it can cause side effects such as nausea, fatigue, and elevated liver enzymes. Patients should be monitored closely by healthcare professionals. Adverse effects can be minimized with proper dosing and patient education on precautionary measures.

How should Pacritinib (CAS: 937272-79-2) be stored?

Pacritinib should be stored at room temperature, between 15°C to 30°C (59°F to 86°F), away from direct sunlight and moisture. It should be kept in a tightly sealed container to protect it from environmental conditions that could alter its efficacy or stability. Proper storage is crucial for maintaining the drug's quality and safety during use.