![3-[4-(difluoromethoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid structure](https://static.chemtradehub.com/structs/149/1496564-27-2-952e.webp "3-[4-(difluoromethoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid structure")
3-[4-(difluoromethoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS Number:
1496564-27-2
Molecular Formula:
C25H21F2NO5
Syntheses of 2-(2,2,2-trifluoroethylidene)/(2,2-difluoroethyl)-1,3-dicarbonyl compounds and their fungicidal activities
Literature Information
Publication Date
2018-12-07
DOI
10.1039/C8QO01118D
Impact Factor
5.281
Authors
Yueji Chen, Yi You, Zhiqiang Weng
View Original
Abstract
A Knoevenagel-type reaction of 1,3-diketone substrates with trifluoroacetic anhydride is described. The electrophilic species of trifluoroacetaldehyde is easily generated in situ by the reaction of trifluoroacetic anhydride/difluoroacetic anhydride with triethylamine. By this efficient and simple approach, a library of 2-(2,2,2-trifluoroethylidene)-1,3-dicarbonyl compounds that contain a wide range of functional groups were synthesized in good yields. Moreover, the reaction with difluoroacetic anhydride affords the corresponding (2,2-difluoroethyl)-1,3-dicarbonyls. Some of these compounds exhibited promising fungicidal activities.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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