A facile approach to synthesize azaindoline functionalized spirocarbocyclic scaffolds via a Pd-catalyzed cascade cyclization/dearomatization process
Literature Information
Publication Date
2018-10-09
DOI
10.1039/C8QO00964C
Impact Factor
5.281
Authors
Xin-Xing Wu, Hui Tian, Yu Wang, Anjia Liu, Hengfan Chen, Zhixiang Fan, Xuefeng Li, Shufeng Chen
View Original
Abstract
A novel construction of azaindoline functionalized spirocarbocyclic scaffolds bearing two all-carbon quaternary centers has been developed via a palladium-catalyzed Heck cyclization/phenol dearomatization reaction. In the cascade process, three new C(sp2)–C(sp3) bonds are formed in a single chemical operation. The approach shows broad substrate scope and good functional-group tolerance.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(1-(2-(Dimethylamino)ethyl)-1H-pyrazol-4-yl)boronic acid
CAS Number:
1086063-73-1
Molecular Formula:
C7H14BN3O2
![2-[(E)-(2-Methoxyphenyl)diazenyl]-3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide structure](https://static.chemtradehub.com/structs/821/82199-12-0-f1d0.webp "2-[(E)-(2-Methoxyphenyl)diazenyl]-3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide structure")
2-[(E)-(2-Methoxyphenyl)diazenyl]-3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide
CAS Number:
82199-12-0
Molecular Formula:
C18H17N5O4
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