Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

Literature Information

Publication Date 2018-09-06
DOI 10.1039/C8OB02018C
Impact Factor 3.876
Authors

Chandra Mohan Kurmarayuni, Baby Ramana Mutchu, Ramana Tamminana, Hari Babu Bollikolla


View Original

Abstract

A novel, convenient and efficient protocol for the construction of various 2-aminophenyl benzothiazoles by domino intra- and intermolecular C–N cross-coupling reactions of arylisothioureas with aryl iodides using an inexpensive, air stable and readily available copper catalyst is described. The arylisothioureas were obtained from thiourea via copper promoted desulfurization followed by nucleophilic substitution. In addition, the reactivity of arylhalides and the reaction mechanism have also been studied. The protocol features operational simplicity and a broad substrate scope.

Related Literature

Real time plasmonic qPCR: how fast is ultra-fast? 30 cycles in 54 seconds

Philip J. R. Roche, Mohamed Najih, Seung S. Lee, Lenore K. Beitel, Matthew L. Carnevale, Andrew G. Kirk

2017-04-12 Paper

DOI: 10.1039/C7AN00304H

Ultra-filtration of human serum for improved quantitative analysis of low molecular weight biomarkers using ATR-IR spectroscopy

Franck Bonnier, Clément Wasselet, Guillaume Brachet, Renaud Respaud, Luis Felipe C. S. Carvalho, Dominique Bertrand, Matthew J. Baker, Hugh J. Byrne, Igor Chourpa

2016-12-08 Paper

DOI: 10.1039/C6AN01888B

NIR two-photon fluorescent probe for biothiol detection and imaging of living cells in vivo

Xiang Xia, Ying Qian

2018-09-20 Paper

DOI: 10.1039/C8AN01605D

Rapid infrared mapping for highly accurate automated histology in Barrett's oesophagus

G. R. Lloyd, J. Nallala, M. Isabelle, L. M. Almond, N. A. Shepherd, C. A. Kendall, A. C. Shore, N. Stone

2016-10-03 Paper

DOI: 10.1039/C6AN01871H

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39)

Sang-Yong Lee, Xihuan Luo, Vigneshwaran Namasivayam, Jennifer Geiss, Salahuddin Mirza, Julie Pelletier, Holger Stephan, Christa E. Müller

2018-10-02 Paper

DOI: 10.1039/C8AN01108G

Inside front cover

Cover

DOI: 10.1039/C8AN90085J

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning

M. R. Siddique, A. V. Rutter, K. Wehbe, G. Cinque, G. Bellisola

2016-12-08 Paper

DOI: 10.1039/C6AN01914E

2D europium coordination polymer as a regenerable fluorescence probe for efficiently detecting fipronil

Shuai-Liang Yang, Jiu-Nan Lu, Sai-Jun Zhang

2018-08-27 Paper

DOI: 10.1039/C8AN00701B

Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients

Jane Bryant, John Armstrong, Mary Dunne, Marie Finn

2016-12-13 Paper

DOI: 10.1039/C6AN02100J

You might also like

Compound Q&A

What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?

N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...

52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A

What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?

When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...

1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A

What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?

Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...

628-39-7Diethyldiselane
Compound Q&A

What is the market or research trend for oxocopper (CAS: 12053-18-8)?

The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...

12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A

What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?

The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...

1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A

What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?

2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...

35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A

What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?

2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...

91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A

How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...

129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A

What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?

3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...

4857-42-53-Methyl-1,2-oxazole...
Compound Q&A

How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?

Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...

1281816-04-3Lys-SMCC-DM1

Source Journal

Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
Self-citation Rate: 10.3%
Articles per Year: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.