Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

Literature Information

Publication Date 2018-03-07
DOI 10.1039/C8OB00329G
Impact Factor 3.876
Authors

Susan E. Hagen, Kun Liu, Yafei Jin, Lolita Piersimoni, Hollis D. Showalter


View Original

Abstract

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts. Each exhibits high aqueous solubility, excellent protein crosslinking efficiencies, low collision induced dissociation (CID) energy fragmentation efficiencies, high stoichiometries of reaction, increased charges of crosslinked peptide ions, and maintenance of overall surface charge balance of crosslinked proteins.

Related Literature

Inside front cover

Front/Back Matter

DOI: 10.1039/B803675F

Back cover

Front/Back Matter

DOI: 10.1039/B804660N

A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid‡

Ruth I. J. Amos, Brendon S. Gourlay, Brian F. Yates

2008-02-08 Communication

DOI: 10.1039/B719570B

Front cover

Cover

DOI: 10.1039/B805398G

Macromolecular complexation of poly(methylenephosphine) to gold(i): a facile route to highly metallated polymers

Bronwyn H. Gillon, Brian O. Patrick, Derek P. Gates

2008-03-28 Communication

DOI: 10.1039/B719199E

Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

Suresh R. Chawrai, Neil R. Williamson, George P. C. Salmond, Finian J. Leeper

2008-02-05 Communication

DOI: 10.1039/B719353J

A new NCN pincer ruthenium complex and its catalytic activity for enantioselective hydrogenation of ketones

Jun-ichi Ito, Satoshi Ujiie, Hisao Nishiyama

2008-03-12 Communication

DOI: 10.1039/B800387D

Preparation of silyl substituted crotylzinc reagents and their highly diastereoselectiveaddition to carbonyl compounds

Matthew D. Helm, Peter Mayer, Paul Knochel

2008-03-19 Communication

DOI: 10.1039/B802157K

A simple method for the containment and purification of filled open-ended single wall carbon nanotubes using C60 molecules

Lidong Shao, Tsung-Wu Lin, Gerard Tobias, Malcolm L. H. Green

2008-03-05 Communication

DOI: 10.1039/B800881G

You might also like

Compound Q&A

What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?

N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...

52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A

What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?

When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...

1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A

What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?

Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...

628-39-7Diethyldiselane
Compound Q&A

What is the market or research trend for oxocopper (CAS: 12053-18-8)?

The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...

12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A

What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?

The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...

1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A

What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?

2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...

35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A

What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?

2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...

91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A

How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...

129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A

What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?

3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...

4857-42-53-Methyl-1,2-oxazole...
Compound Q&A

How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?

Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...

1281816-04-3Lys-SMCC-DM1

Source Journal

Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
Self-citation Rate: 10.3%
Articles per Year: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.