Chemoenzymatic synthesis of prodigiosin analogues—exploring the substrate specificity of PigC

Literature Information

Publication Date 2008-02-05
DOI 10.1039/B719353J
Impact Factor 6.222
Authors

Suresh R. Chawrai, Neil R. Williamson, George P. C. Salmond, Finian J. Leeper


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Abstract

Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, PigC, has a relaxed substrate-specificity.

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