A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid‡
Literature Information
Ruth I. J. Amos, Brendon S. Gourlay, Brian F. Yates
Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.
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