A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid‡

Literature Information

Publication Date 2008-02-08
DOI 10.1039/B719570B
Impact Factor 6.222
Authors

Ruth I. J. Amos, Brendon S. Gourlay, Brian F. Yates


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Abstract

Herein we report radical trapping experiments that support the formation of an acyl radical as the active species from the oxidation of isoniazid; these data provide insight into the mechanism of hydrazide oxidation.

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