![2-Azaspiro[4.5]decane-3,8-dione structure](https://static.chemtradehub.com/structs/914/914780-96-4-e94b.webp "2-Azaspiro[4.5]decane-3,8-dione structure")
Minimising conformational bias in fluoroprolines through vicinal difluorination‡
Literature Information
Publication Date
2018-04-16
DOI
10.1039/C8CC01493K
Impact Factor
6.222
Authors
Emile Ottoy, Mark E. Light, Bruno Kieffer, Ilya Kuprov, Jose C. Martins, Davy Sinnaeve, Bruno Linclau
View Original
Abstract
Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry
Recommended Compounds
![[3-Fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]boronic acid structure](https://static.chemtradehub.com/structs/874/874289-09-5-e3d4.webp "[3-Fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]boronic acid structure")
[3-Fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]boronic acid
CAS Number:
874289-09-5
Molecular Formula:
C11H13BFNO3
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