Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

Literature Information

Publication Date 2018-01-30
DOI 10.1039/C7PY02050C
Impact Factor 5.582
Authors

E. Lestini, L. D. Blackman, C. M. Zammit, R. J. Williams, M. Inam, B. Couturaud, R. K. O'Reilly


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Abstract

Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.

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