Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction
Literature Information
John M. Gardiner, Philip D. Crewe, Gillian E. Smith, Kenneth T. Veal
A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87–90% e.e.
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