First synthesis of an amythiamicin pyridine cluster

Literature Information

Publication Date 2003-11-25
DOI 10.1039/B310944E
Impact Factor 6.222
Authors

Mark C. Bagley, James W. Dale, Robert L. Jenkins, Justin Bower


View Original

Abstract

The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93% ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition窶田yclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.

Related Literature

Front cover

2021-07-27 Cover

DOI: 10.1039/D1RE90032C

Tracing the reactivity of single atom alloys for ethanol dehydrogenation using ab initio simulations

Jayendran Iyer, Fatima Jalid, Tuhin S. Khan, M. Ali Haider

2021-11-23 Paper

DOI: 10.1039/D1RE00396H

Front cover

2021-11-24 Cover

DOI: 10.1039/D1RE90047A

Renewable dimethyl carbonate for tertiary amine quaternisation: kinetic measurements and process optimisation

Roel J. T. Kleijwegt, Vera C. Henricks, Wyatt Winkenwerder, Wim Baan, John van der Schaaf

2021-08-09 Paper

DOI: 10.1039/D1RE00191D

Inside back cover

2021-08-24 Cover

DOI: 10.1039/D1RE90038B

Exponential growth of functional poly(glutamic acid)dendrimers with variable stereochemistry

Sebastian Hartwig, Mary M. Nguyen, Stefan Hecht

2009-11-25 Communication

DOI: 10.1039/B9PY00217K

Inside front cover

2021-11-24 Cover

DOI: 10.1039/D1RE90048J

Highly selective production of benzylamine from benzonitrile on metal-supported catalysts

Darío J. Segobia, Andrés F. Trasarti, Carlos R. Apesteguía

2021-08-13 Paper

DOI: 10.1039/D1RE00234A

Dispersion nitroxide mediated polymerization of methyl methacrylate in supercritical carbon dioxide using in situ formed stabilizers

Bruno Grignard, Trang Phan, Denis Bertin, Didier Gigmes, Christine Jérôme, Christophe Detrembleur

2010-04-13 Communication

DOI: 10.1039/C0PY00066C

Sequential removal and recovery of cadmium ions (Cd2+) using photocatalysis and reduction crystallization from the aqueous phase

Vivek Kumar, Ravinder Kumar Wanchoo, Amrit Pal Toor

2021-06-28 Paper

DOI: 10.1039/D1RE00149C

You might also like

Compound Q&A

What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?

When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...

16712-20-2Lithium chloride hyd...
Compound Q&A

Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?

4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...

690261-92-84-(4H-1,2,4-Triazol-...
Compound Q&A

How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?

Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...

16733-85-01,3-Thiazole-2-carbo...
Compound Q&A

What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?

5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...

934175-58-35-(Difluoromethyl)-2...
Compound Q&A

How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?

Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...

22288-79-5Methyl 3-acetamido-2...
Compound Q&A

What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?

4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...

34846-65-64-Isoquinolinecarbon...
Compound Q&A

How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?

Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...

877309-59-6Methyl 1H-1,2,3-tria...
Compound Q&A

What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?

6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...

1160791-13-86-Bromo[1,3]thiazolo...
Compound Q&A

Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?

(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...

23651-95-8(2S,3S)-2-Ammonio-3-...
Compound Q&A

What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?

7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....

1293987-84-47-bromo-3-methyl-3,4...

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.