Stimuli-responsive, biocompatible hydrogel derived from glycogen and poly(N-isopropylacrylamide) for colon targeted delivery of ornidazole and 5-amino salicylic acid

Literature Information

Publication Date 2016-07-26
DOI 10.1039/C6PY01128D
Impact Factor 5.582
Authors

Priyapratim Patra, Arun Prabhu Rameshbabu, Dipankar Das, Santanu Dhara, Asit Baran Panda, Sagar Pal


View Original

Abstract

In the present article, a novel biocompatible and stimuli-responsive hydrogel (cl-Gly/pNIPAm) has been fabricated through free radical polymerisation using biopolymer glycogen (Gly), N-isopropylacrylamide (NIPAm) monomer and ethylene glycol dimethacrylate (EGDMA) crosslinker. Several grades of hydrogels have been developed and an optimized grade (i.e. c-Gly/NIPAm 4 with higher % crosslinking) has been used for characterisation and application towards colon targeted drugs carrier. The temperature and pH sensitivity of the cl-Gly/pNIPAm hydrogel have been studied by assessing equilibrium swelling at 25/37 °C and pH 1.2/7.4. The LCST of the developed hydrogel has been determined and found to be in the range of 32.5–34 °C. The degradation kinetics of the hydrogel has been performed. The hydrogel demonstrates good compatibility towards human mesenchymal stem cells (hMSCs). It is degraded by hen egg lysozyme. The synthesized hydrogel can load colon targeted drugs, 5-amino salicylic acid (5-ASA) and ornidazole, efficiently and released both drugs in a controlled manner, while ∼96–97% of drugs remained stable after 2 months. The release kinetics and mechanism have also been studied.

Related Literature

Interfacial modification of organic photovoltaic devices by molecular self-organization

Akira Tada, Motoshi Nakamura, Qingshuo Wei

2012-01-20 Perspective

DOI: 10.1039/C2CP40198C

Metal–organic framework supported ionic liquid membranes for CO2 capture: anion effects

Krishna M. Gupta, Yifei Chen, Zhongqiao Hu, Jianwen Jiang

2012-03-20 Paper

DOI: 10.1039/C2CP23972H

Spatial heterogeneity in a lyotropic liquid crystal with hexagonal phase

David P. Penaloza, Jr., Koichiro Hori, Atsuomi Shundo

2012-02-28 Communication

DOI: 10.1039/C2CP40284J

Contents list

Front/Back Matter

DOI: 10.1039/C2CP90029G

Electro-catalytic oxidative cleavage of lignin in a protic ionic liquid

Elena Reichert, Reiner Wintringer, Dietrich A. Volmer, Rolf Hempelmann

2012-02-07 Paper

DOI: 10.1039/C2CP23596J

Properties of metastable linkage NO isomers in Na2[Fe(CN)5NO]·2H2O incorporated in mesopores of silica xerogels

Zakaria Tahri, Robert Lepski, Kuan-Ying Hsieh, El-Eulmi Bendeif, Sebastien Pillet, Pierrick Durand, Theo Woike, Dominik Schaniel

2012-02-08 Paper

DOI: 10.1039/C2CP23607A

Dielectric relaxation and ultrafast transient absorption spectroscopy of [C6mim]+[Tf2N]−/acetonitrile mixtures

Nils Bartels, Alexander Stoppa, Richard Buchner, Thomas Lenzer, Kawon Oum

2012-02-07 Paper

DOI: 10.1039/C2CP23704K

The effect of concentration on Li diffusivity and conductivity in rutile TiO2

Handan Yildirim, Jeffrey P. Greeley, Subramanian K. R. S. Sankaranarayanan

2012-02-22 Paper

DOI: 10.1039/C2CP22731B

On the structure of the Au18(SR)14 cluster

Alfredo Tlahuice, Ignacio L. Garzón

2012-01-27 Communication

DOI: 10.1039/C2CP24016E

You might also like

Compound Q&A

What is 3-Fluoro-2-methylbenzylamine (CAS: 771573-36-5)?

3-Fluoro-2-methylbenzylamine is an organic compound with the CAS number 771573-3...

771573-36-53-Fluoro-2-methylben...
Compound Q&A

Is Tert-butyl 2-(oxetan-3-ylidene)acetate (CAS: 1207175-03-8) safe?

Tert-butyl 2-(oxetan-3-ylidene)acetate is considered safe for its intended uses ...

1207175-03-8Tert-butyl 2-(oxetan...
Compound Q&A

What precautions should be taken when handling 4-Acetyl-2-fluorobenzonitrile (CAS: 214760-18-6)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab co...

214760-18-64-Acetyl-2-fluoroben...
Compound Q&A

How is 2-Ethyl-4-methyl-1,3-thiazole (CAS: 15679-12-6) typically synthesized?

2-Ethyl-4-methyl-1,3-thiazole is commonly synthesized via the reaction of thiour...

15679-12-62-Ethyl-4-methyl-1,3...
Compound Q&A

How should 5',5''-([2,2'-Bithiophene]-5,5'-diyl)bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid)) (CAS: 1227780-71-3) be stored?

This compound should be stored in a cool, dry place away from direct sunlight an...

1227780-71-35',5''''-([2,2'-Bith...
Compound Q&A

What regulatory guidelines apply to L-Lysine Acetate Salt (CAS: 52315-92-1)?

L-Lysine Acetate Salt (CAS: 52315-92-1) is subject to various regulatory guideli...

52315-92-1L-LYSINE ACETATE SAL...
Compound Q&A

Is 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) safe?

6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) is generally conside...

259793-96-96-Fluoro-3-hydroxy-2...
Compound Q&A

What are the physical and chemical properties of 1,1'-Sulfonylbis(1H-imidazole) (CAS: 7189-69-7)?

1,1'-Sulfonylbis(1H-imidazole) is a crystalline solid with a molecular weight of...

7189-69-71,1'-Sulfonylbis(1H-...
Compound Q&A

What industries use 4-methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5)?

4-Methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5) is primarily used i...

289483-82-54-methyl-7-nitro-1H-...
Compound Q&A

How should waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) be handled?

Waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) should be ...

97753-82-75-Bromo-3-indolyl-be...

Source Journal

Polymer Chemistry

Polymer Chemistry
CiteScore: 8.6
Self-citation Rate: 7.3%
Articles per Year: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.