Electrocatalytic monitoring of peptidic proton-wires

Literature Information

Publication Date 2016-06-15
DOI 10.1039/C6AN00869K
Impact Factor 4.616
Authors

V. Dorčák, M. Kabeláč, O. Kroutil, K. Bednářová, J. Vacek


View Original

Abstract

The transfer of protons or proton donor/acceptor abilities is an important phenomenon in many biomolecular systems. One example is the recently proposed peptidic proton-wires (H-wires), but the ability of these His-containing peptides to transfer protons has only been studied at the theoretical level so far. Here, for the first time the proton transfer ability of peptidic H-wires is examined experimentally in an adsorbed state using an approach based on a label-free electrocatalytic reaction. The experimental findings are complemented by theoretical calculations at the ab initio level in a vacuum and in an implicit solvent. Experimental and theoretical results indicated Ala3(His–Ala2)6 to be a high proton-affinity peptidic H-wire model. The methodology presented here could be used for the further investigation of the proton-exchange chemistry of other biologically or technologically important macromolecules.

Related Literature

Luminescent Ln3+ nitrobenzoato complexes: first examples of sensitization of green and red emission

Ana de Bettencourt Dias, Subha Viswanathan

2004-03-23 Communication

DOI: 10.1039/B402038C

Manganese N-confused porphyrin reactivity: CH bond activation and meso carbon reduction

John D. Harvey, Christopher J. Ziegler

2003-10-22 Communication

DOI: 10.1039/B310522A

On the relative migratory aptitudes of carbon and heteroatoms in borate complexes. A surprising α-thia effect

Jonathan M. Stoddard, Kenneth J. Shea

2004-02-27 Communication

DOI: 10.1039/B311292F

New dibenzofuran-bridged bis(amidoamine) and bis(ethylenediamine) ligands and their dinuclear zinc and aluminium complexes

Mark L. Hlavinka, John R. Hagadorn

2003-09-26 Communication

DOI: 10.1039/B309732C

Detecting proximities between quadrupolar nuclei by double-quantum NMR

Gregor Mali, Francis Taulelle

2004-02-27 Communication

DOI: 10.1039/B316807G

Structural characterisation of the first mononuclear bismuth porphyrin

Bernard Boitrel, Zakaria Halime, Lydie Michaudet, Mohamed Lachkar, Loïc Toupet

2003-09-30 Communication

DOI: 10.1039/B309615G

Noncovalent attachment of oxidenanoparticles onto carbon nanotubes using water-in-oil microemulsions

Jing Sun, Lian Gao, Mikio Iwasa

2004-02-27 Communication

DOI: 10.1039/B400817K

First in-situSAXS studies of the mesostructuration of spherical silica and titania particles during spray-drying process

C. Boissiere, D. Grosso, H. Amenitsch, A. Gibaud, A. Coupé, N. Baccile, C. Sanchez

2003-10-14 Communication

DOI: 10.1039/B308694A

Total synthesis of the thiopeptide amythiamicin D

Rachael A. Hughes, Stewart P. Thompson, Lilian Alcaraz, Christopher J. Moody

2004-03-16 Communication

DOI: 10.1039/B401580K

You might also like

Compound Q&A

What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?

N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...

52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A

What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?

When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...

1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A

What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?

Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...

628-39-7Diethyldiselane
Compound Q&A

What is the market or research trend for oxocopper (CAS: 12053-18-8)?

The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...

12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A

What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?

The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...

1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A

What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?

2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...

35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A

What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?

2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...

91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A

How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...

129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A

What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?

3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...

4857-42-53-Methyl-1,2-oxazole...
Compound Q&A

How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?

Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...

1281816-04-3Lys-SMCC-DM1

Source Journal

Analyst

Analyst
CiteScore: 7.8
Self-citation Rate: 5.6%
Articles per Year: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.