Facile fabrication of ultrathin antibacterial hydrogel films via layer-by-layer “click” chemistry

Literature Information

Publication Date 2014-07-23
DOI 10.1039/C4PY00900B
Impact Factor 5.582
Authors

Huan Wang, Guangyu Zha, Hong Du, Lilong Gao, Xiaodong Li, Zhiquan Shen, Weipu Zhu


View Original

Abstract

We report a facile strategy to fabricate ultrathin hydrogel films via a layer-by-layer (LbL) technique and “click” chemistry. Poly[oligo(ethylene glycol)fumarate]-co-poly[dodecyl bis(2-hydroxyethyl)methylammonium fumarate] (POEGDMAM) containing multi-enes and poly[oligo(ethylene glycol)mercaptosuccinate] (POEGMS) containing multi-thiols were synthesized by polycondensation, which were used as precursors for a LbL thiol–ene “click” reaction under ambient conditions without any metal catalyst or light irradiation. Due to the presence of ammonium groups with long alkyl chains in the POEGDMAM, the ultrathin hydrogel films exhibited excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli, which was enhanced by increasing the number of layers. These kinds of biocompatible, antibacterial, ultrathin hydrogel films are promising candidates for biomedical applications.

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Polymer Chemistry

Polymer Chemistry
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