Aztreonam USP Related Compound A (Open-ring Aztreonam)
CAS Number:
87500-74-1
Molecular Formula:
C13H19N5O9S2
Facile fabrication of ultrathin antibacterial hydrogel films via layer-by-layer “click” chemistry
Literature Information
Publication Date
2014-07-23
DOI
10.1039/C4PY00900B
Impact Factor
5.582
Authors
Huan Wang, Guangyu Zha, Hong Du, Lilong Gao, Xiaodong Li, Zhiquan Shen, Weipu Zhu
View Original
Abstract
We report a facile strategy to fabricate ultrathin hydrogel films via a layer-by-layer (LbL) technique and “click” chemistry. Poly[oligo(ethylene glycol)fumarate]-co-poly[dodecyl bis(2-hydroxyethyl)methylammonium fumarate] (POEGDMAM) containing multi-enes and poly[oligo(ethylene glycol)mercaptosuccinate] (POEGMS) containing multi-thiols were synthesized by polycondensation, which were used as precursors for a LbL thiol–ene “click” reaction under ambient conditions without any metal catalyst or light irradiation. Due to the presence of ammonium groups with long alkyl chains in the POEGDMAM, the ultrathin hydrogel films exhibited excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli, which was enhanced by increasing the number of layers. These kinds of biocompatible, antibacterial, ultrathin hydrogel films are promising candidates for biomedical applications.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
2-Methyl-2-propanyl (2R)-2-formyl-1-piperidinecarboxylate
CAS Number:
134526-69-5
Molecular Formula:
C11H19NO3
![(2E)-4-[(1R,2S,8R,19S,21R)-14-Hydroxy-11-isopropenyl-8,23,23-trimethyl-5-(3-methyl-2-buten-1-yl)-16,20-dioxo-3,7,22-trioxaheptacyclo[17.4.1.1~8,12~.0~2,17~.0~2,21~.0~4,15~.0~6,13~]pentacosa-4(15),5,13
,17-tetraen-21-yl]-2-methyl-2-butenoic acid structure](https://static.chemtradehub.com/structs/173/173867-04-4-d2d3.webp "(2E)-4-[(1R,2S,8R,19S,21R)-14-Hydroxy-11-isopropenyl-8,23,23-trimethyl-5-(3-methyl-2-buten-1-yl)-16,20-dioxo-3,7,22-trioxaheptacyclo[17.4.1.1~8,12~.0~2,17~.0~2,21~.0~4,15~.0~6,13~]pentacosa-4(15),5,13
,17-tetraen-21-yl]-2-methyl-2-butenoic acid structure")
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