A general and practical palladium-catalyzed monoarylation of β-methyl C(sp3)–H of alanine
Literature Information
Publication Date
2014-09-16
DOI
10.1039/C4CC06652A
Impact Factor
6.222
Authors
Kai Chen, Shuo-Qing Zhang, Jing-Wen Xu, Fang Hu, Bing-Feng Shi
View Original
Abstract
A palladium-catalyzed monoarylation of β-methyl C(sp3)–H of an alanine derivative with aryl iodides using an 8-aminoquinoline auxiliary is described. The reaction is highly efficient, scalable and compatible with a variety of functional groups with complete retention of chirality, providing a general and practical access to various β-aryl-α-amino acids. The synthetic potential of this protocol is further demonstrated in the sequential synthesis of diverse β-branched α-amino acids.
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Source Journal
Chemical Communications
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8.6
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4.7%
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2-(5-Bromo-1H-pyrrolo[2,3-B]pyridin-3-YL)acetic acid
CAS Number:
1060795-03-0
Molecular Formula:
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4-(4-Chloro-2-methoxyphenyl)-3-fluorobenzoic acid
CAS Number:
1261970-23-3
Molecular Formula:
C14H10ClFO3
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