Two birds with one stone: dendrimer surface engineering enables tunable periphery hydrophobicity and rapid endosomal escape
Literature Information
Zheng Wang, Chao Chen, Ruihong Liu, Aiping Fan, Deling Kong, Yanjun Zhao
Multifunctional thermosensitive dendrimeric nanocarriers were generated via tailored surface modification. Such design not only facilitated the rapid endosomal escape of dendrimers, but also achieved tunable surface hydrophobicity, which could be employed to achieve on-demand cargo release. These smart dendrimers are promising for enhancing intracellular drug delivery.
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