Synthesis of chemically pure, luminescent Eu3+ doped HAp nanoparticles: a promising fluorescent probe for in vivo imaging applications

Literature Information

Publication Date 2013-04-12
DOI 10.1039/C3CP42648C
Impact Factor 3.676
Authors

S. Sasanka Kumar, Manoj Komath, Manoj Raama Varma, M. K. Jayaraj, K. Rajeev Kumar


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Abstract

The poor solubility, poor biocompatibility and disposal issues make fluorescent quantum dots such as CdSe, CdS, ZnS, InP, InAs, etc. impractical for imaging tissues or intercellular structures. As calcium phosphate is the main inorganic component of human bone and teeth, hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is highly biocompatible and bioactive. Since HAp nanoparticles are not luminescent, a novel inorganic biocompatible fluorescent probe was suggested by doping HAp with lanthanides. Here we report the growth of chemically pure fluorescent HAp nanoparticles synthesized by a new methodology, liquid phase pulsed laser ablation using third harmonics (355 nm) of Nd-YAG laser. Europium doped HAp nanoparticles show emission with prominent peaks at 531 nm, 572 nm, 601 nm and 627 nm upon excitation at a wavelength of 325 nm. The red luminescence could also be observed under visible excitation at 459 nm and is suitable for living cell applications.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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