β-Amidoaldehydes viaoxazolinehydroformylation‡

Literature Information

Publication Date 2009-09-01
DOI 10.1039/B913698C
Impact Factor 6.222
Authors

David S. Laitar, John W. Kramer, Bryan T. Whiting, Emil B. Lobkovsky, Geoffrey W. Coates


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Abstract

4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.

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