Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

Literature Information

Publication Date 2009-04-22
DOI 10.1039/B904185K
Impact Factor 6.222
Authors

Ishwar Singh, Joseph S. Vyle, Frances Heaney


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Abstract

Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

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