The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

Literature Information

Publication Date 2008-09-23
DOI 10.1039/B813369G
Impact Factor 6.222
Authors

Yu Sung Chun, Ki Kon Lee, Young Ok Ko, Hyunik Shin, Sang-gi Lee


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Abstract

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

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