The first general method for α-trifluoromethylation of carboxylic acids using BrF3

Literature Information

Publication Date 2004-02-09
DOI 10.1039/B315705A
Impact Factor 6.222
Authors

Aviv Hagooly, Shlomo Rozen


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Abstract

2-Carbomethoxy-1,1-bis(methylsulfide)-1-alkenes, easily made from carboxylic acids, CS2 and MeI, were treated with BrF3 producing eventually the desired α-trifluoromethyl carboxylate derivatives – RCH(CF3)COOR′ – in good yields.

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