Photoactivatable HNO-releasing compounds using the retro-Diels–Alder reaction

Literature Information

Publication Date 2008-09-23
DOI 10.1039/B811985F
Impact Factor 6.222
Authors

Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki, Naoki Miyata


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Abstract

We synthesized hetero-Diels–Alder cycloadducts from acyl nitroso derivatives and 9,10-dimethylanthracene, to be photo-inducible HNO-releasing agents and found that introduction of conjugated nitroaromatic groups effectively enhanced the responsiveness of HNO release to UV-A irradiation; we confirmed photoinduced HNO formation by EPR and GCMS analysis.

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