G-quadruplex-based DNAzyme for facile colorimetric detection of thrombin

Literature Information

Publication Date 2008-06-09
DOI 10.1039/B805565C
Impact Factor 6.222
Authors

Tao Li, Erkang Wang, Shaojun Dong


View Original

Abstract

Thrombin-binding aptamer is found to bind hemin to form a catalytic complex whose activity is significantly promoted by the addition of thrombin, which enables the colorimetric detection of thrombin with high specificity and sensitivity in a facile way.

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