Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray

Literature Information

Publication Date 2007-03-15
DOI 10.1039/B702826A
Impact Factor 6.222
Authors

Mahesh Uttamchandani, Kai Liu, Resmi C. Panicker


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Abstract

A panel of 20 peptide vinyl sulfone probes has been synthesized and used to generate activity-based fingerprinting profiles of cysteine proteases in both gel- and microarray-based formats; the inhibitor fingerprints of representative small molecule inhibitors targeted against 4 cysteine proteases were also obtained, in high-throughput, using the same protein microarray platform.

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