Carotenoids can act as antioxidants by oxidizing the superoxideradical anion

Literature Information

Publication Date 2009-11-06
DOI 10.1039/B917636E
Impact Factor 3.676
Authors

Annia Galano, Ana Martínez


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Abstract

The electron transfer (ET) reaction between carotenoids and the superoxide radical anion is found to be not only a viable process but also a very unique one. The nature of the O2˙− inverts the direction of the transfer, with respect to ET involving other ROS: the O2˙− becomes the electron donor and carotenoids (CAR) the electron acceptor. Therefore the “antioxidant” activity of CAR when reacting with O2˙− lies in their capacity to prevent the formation of oxidant ROS. This peculiar charge transfer is energetically feasible in non-polar environments but not in polar media. In addition the relative reactivity of CAR towards O2˙− is drastically different from their reactivity to other ROS. Asthaxanthin (ASTA) is predicted to be a better O2˙− quencher than LYC and the other CAR. The CAR + O2˙− reactions were found to be diffusion controlled. The agreement with available experimental data supports the density functional theory results from the present work.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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