Hemiaminals as substrates for sulfur ylides: Direct asymmetric syntheses of functionalised pyrrolidines and piperidines

Literature Information

Publication Date 2006-04-13
DOI 10.1039/B602226J
Impact Factor 6.222
Authors

Christoforos G. Kokotos, Varinder K. Aggarwal


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Abstract

Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enantioselectivity. The reaction can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf.

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