EthylenediaminetetraaceticacidcalciumDisodiumsalthydrate
CAS Number:
23411-34-9
Molecular Formula:
C10H16CaN2Na2O10
Quantitative visualization and detection of acetylcholinesterase activity and its inhibitor based on the oxidation character of ultrathin MnO2 nanosheets
Literature Information
Publication Date
2019-09-10
DOI
10.1039/C9AY01721F
Impact Factor
2.896
Authors
Xian-Hua Meng, Dang Lan Huong, Won Keun Oh, Wei-Feng Wang, Jun-Li Yang
View Original
Abstract
Acetylcholinesterase (AChE) is the key enzyme in the treatment of Alzheimer's disease (AD). In this study, we designed a novel visualization biosensing system for the quantitative detection of AChE and its inhibitors. The MnO2–OPD platform showed the broad detection of AChE ranging from 0.49–98 U L−1 and the LOD was 0.13 U L−1. Furthermore, the AChE–MnO2–OPD biosensing system was successfully applied to screen AChE inhibitors from a natural product library (Northwestern China Plant Natural Material Bank). 3,4-Dihydroxyphenylethanol (HJ-38), a natural product isolated from Zanthoxylum bungeanum pericarps, was found to be a potent AChE inhibitor with an IC50 of 2.8 μM and is comparable to the positive control tacrine with an IC50 of 1.3 μM. Furthermore, a cell-based assay confirmed the neuro-protective potential of compound HJ-38, which supported the practicability of the established AChE–MnO2–OPD biosensing system.
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Source Journal
Analytical Methods
CiteScore:
5.1
Self-citation Rate:
3.7%
Articles per Year:
655
Analytical Methods welcomes early applications of new analytical and bioanalytical methods and technology demonstrating the potential for societal impact. We require that methods and technology reported in the journal are sufficiently innovative, robust, accurate, and compared to other available methods for the intended application. Developments with interdisciplinary approaches are particularly welcome. Systems should be proven with suitably complex and analytically challenging samples. We encourage developments within, but not limited to, the following technologies and applications: global health, point-of-care and molecular diagnostics biosensors and bioengineering drug development and pharmaceutical analysis applied microfluidics and nanotechnology omics studies, such as proteomics, metabolomics or glycomics environmental, agricultural and food science neuroscience biochemical and clinical analysis forensic analysis industrial process and method development
Recommended Compounds
![Sodium (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)-2-heptenoate structure](https://static.chemtradehub.com/structs/811/81129-83-1-441c.webp "Sodium (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)-2-heptenoate structure")
Sodium (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)-2-heptenoate
CAS Number:
81129-83-1
Molecular Formula:
C16H25N2NaO5S
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