Highly cytotoxic iron(ii) complexes with pentadentate pyridylligands as a new class of anti-tumor agents

Literature Information

Publication Date 2005-08-19
DOI 10.1039/B507687K
Impact Factor 6.222
Authors

Ella Lai-Ming Wong, Guo-Su Fang, Chi-Ming Che, Nianyong Zhu


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Abstract

The iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.

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