Highly cytotoxic iron(ii) complexes with pentadentate pyridylligands as a new class of anti-tumor agents
Literature Information
Ella Lai-Ming Wong, Guo-Su Fang, Chi-Ming Che, Nianyong Zhu
The iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.
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