A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling

Literature Information

Publication Date 2005-04-06
DOI 10.1039/B502324F
Impact Factor 6.222
Authors

Alexei S. Karpov, Eugen Merkul, Thomas Oeser, Thomas J. J. Müller


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Abstract

A novel sequence of Sonogashira coupling and electrophilic addition to an ynone, with concomitant deprotection and cyclocondensation, opens a new one-pot synthesis of 3-halofurans; the method can be readily elaborated to a new sequential Sonogashira–addition–cyclocondensation–Suzuki reaction to furnish 2,3,5-trisubstituted furans in a one-pot fashion.

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