Facile glycosylation of dendrimers for eliciting specific cell–material interactions
Literature Information
Xiaopeng Liu, Jie Liu, Ying Luo
Taking advantage of the reactivity between reducing glycans and hydrazides, a facile and general approach is demonstrated to conjugate glycan epitopes to polyamidoamine (PAMAM) based dendrimers. Using HepG2 cells, it is shown that parallel studies of different glycodendrimers allowed comparison and identification of multivalent conjugates with specific cell-binding capabilities.
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