Facile glycosylation of dendrimers for eliciting specific cell–material interactions

Literature Information

Publication Date 2011-11-29
DOI 10.1039/C1PY00404B
Impact Factor 5.582
Authors

Xiaopeng Liu, Jie Liu, Ying Luo


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Abstract

Taking advantage of the reactivity between reducing glycans and hydrazides, a facile and general approach is demonstrated to conjugate glycan epitopes to polyamidoamine (PAMAM) based dendrimers. Using HepG2 cells, it is shown that parallel studies of different glycodendrimers allowed comparison and identification of multivalent conjugates with specific cell-binding capabilities.

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