“Polar patch” proteases as glycopeptiligases

Literature Information

Publication Date 2004-12-03
DOI 10.1039/B412030B
Impact Factor 6.222
Authors

Katie J. Doores, Benjamin G. Davis


View Original

Abstract

The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%.

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