Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+

Literature Information

Publication Date 2004-03-23
DOI 10.1039/B316917K
Impact Factor 6.222
Authors

Janice Aldrich-Wright, Craig Brodie, Edith C. Glazer, Nathan W. Luedtke, Lev Elson-Schwab, Yitzhak Tor


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Abstract

Symmetrical homometallic dinuclear complexes of the type [{Ru(dpq)2}2(phen–SOS–phen)]4+, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation constants (Kd) in the nM range.

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DOI: 10.1039/C4CP90148G

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ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

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