H-GLU-AMC | CAS No. 98516-76-8

H-GLU-AMC

Basic Information

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CAS Number

98516-76-8

Molecular Formula

C15H16N2O5

Molecular Weight

304.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCC(=O)O)N

InChI

InChI=1S/C15H16N2O5/c1-8-6-14(20)22-12-7-9(2-3-10(8)12)17-15(21)11(16)4-5-13(18)19/h2-3,6-7,11H,4-5,16H2,1H3,(H,17,21)(H,18,19)/t11-/m0/s1

InChIKey

USALUSONPMPEKY-NSHDSACASA-N

LogP

1.2320199999999997

Topological Polar Surface Area

122.63 Å²

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

502

Synonyms & References

English

SCHEMBL3675104
G-3845
(S)-4-Amino-5-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-5-oxopentanoic acid
FD21418
4-Amino-5-hydroxy-5-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)imino]pentanoic acid
Glu-NH-med
H-GLU-AMC
7-(alpha-Glutamyl)-4-methylcoumarylamide
AKOS027251099
(4S)-4-amino-5-[(4-methyl-2-oxochromen-7-yl)amino]-5-oxopentanoic acid
98516-76-8
alpha-Glutamyl-7-amino-4-methylcoumarylamide
CS-0372838
(S)-4-amino-5-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-5-oxopentanoic acid; H-GLU-AMC
MFCD00051217
(S)-4-Amino-5-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-5-oxopentanoicacid
DTXSID90913231
L-Glutamic acid alpha-(7-amido-4-methylcoumarin)
Pentanoic acid,4-amino-5-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]-5-oxo-, (4S)-
H-Glu-AMC
H-L-Glu-AMC
L-GLUTAMIC ACID ALPHA-(7-AMIDO-4-METHYLCOUMARIN)

MDL Number

MFCD00051217

FAQ

What are the physical and chemical properties of H-GLU-AMC (CAS: 98516-76-8)?

H-GLU-AMC is a crystalline compound with a molecular weight of approximately 347.33 g/mol. It is slightly soluble in water and has good solubility in organic solvents like DMSO. Chemically, it is stable at room temperature but can be reactive in strong bases. It shows good selectivity towards certain enzymes, particularly those involved in the hydrolysis of amide bonds.

How is H-GLU-AMC (CAS: 98516-76-8) typically synthesized?

H-GLU-AMC is typically synthesized by the coupling of amoxicillin with N-hydroxysuccinimide in the presence of a catalyst such as N,N′-dicyclohexylcarbodiimide (DCC) under anhydrous conditions. The reaction yield is around 85%, and the purity can be enhanced through purification techniques like recrystallization.

What industries use H-GLU-AMC (CAS: 98516-76-8)?

H-GLU-AMC is primarily used in the pharmaceutical industry for enzyme inhibition studies and as a substrate for measuring protease activity. It is also utilized in research related to polymers and sensors for its specificity towards certain enzymes.

What precautions should be taken when handling H-GLU-AMC (CAS: 98516-76-8)?

When handling H-GLU-AMC, wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work in a fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent material and proper cleanup procedures. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.