H-GLU-AMC(CAS: 98516-76-8)

H-GLU-AMC is a crystalline compound with a molecular weight of approximately 347.33 g/mol. It is slightly soluble in water and has good solubility in organic solvents like DMSO. Chemically, it is stable at room temperature but can be reactive in strong bases. It shows good selectivity towards certain enzymes, particularly those involved in the hydrolysis of amide bonds.

H-GLU-AMC is typically synthesized by the coupling of amoxicillin with N-hydroxysuccinimide in the presence of a catalyst such as N,N′-dicyclohexylcarbodiimide (DCC) under anhydrous conditions. The reaction yield is around 85%, and the purity can be enhanced through purification techniques like recrystallization.

H-GLU-AMC is primarily used in the pharmaceutical industry for enzyme inhibition studies and as a substrate for measuring protease activity. It is also utilized in research related to polymers and sensors for its specificity towards certain enzymes.

When handling H-GLU-AMC, wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work in a fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent material and proper cleanup procedures. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.