1-Cbz-azetidine-3-carboxylic acid

Basic Information

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CAS Number

97628-92-7

Molecular Formula

C12H13NO4

Molecular Weight

235.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.362

SMILES

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C1C(CN1C(=O)OCC2=CC=CC=C2)C(=O)O

InChI

InChI=1S/C12H13NO4/c14-11(15)10-6-13(7-10)12(16)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,15)

InChIKey

PVJPBKZGIUAESY-UHFFFAOYSA-N

LogP

1.3396000000000001

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

293

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

1-Cbz-Azetidine-3-carboxylic acid
N-(Benzyloxycarbonyl)azetidine-3-carboxylic acid
1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID
1,3-Azetidinedicarboxylicacid, 1-(phenylmethyl) ester
1-phenylmethoxycarbonylazetidine-3-carboxylic acid
Cbz-azetidine-3-carboxylic acid
N-Cbz-azetidine-3-carboxylic acid
N-Carbobenzyloxyazetidine-3-carboxylic acid
1-Benzyloxycarbonylazetidine-3-carboxylic acid
1-Phenylmethoxycarbonylazetidine-3-carboxylic acid
3-Hydroxymethylazetidine-1-carboxylic acid benzyl ester
Azetidine-1,3-dicarboxylic acid monobenzyl ester
Benzyl 3-carboxyazetidine-1-carboxylate
1-Cbz-azetidine-3-carboxylic acid
1-phenylmethoxycarbonylazetidine-3-carboxylic Acid
1-((Benzyloxy)carbonyl)azetidine-3-carboxylic acid
1,3-Azetidinedicarboxylic acid 1-(phenylmethyl) ester
BCP15304
CS-W004868
MFCD09027504
Q-103152
AZETIDINE-1,3-DICARBOXYLIC ACID MONOBENZYL ESTER
1-Cbz-Azetidine-3-carboxylicacid
GS-4033
Z1217190943
1-[(benzyloxy)carbonyl]azetidine-3-carboxylic acid
N-Cbz-Azetidine-3-carboxylic acid
SCHEMBL206638
1-(benzyloxycarbonyl)azetidine-3-carboxylic acid
PB14629
SY018170

MDL Number

MFCD09027504

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-Cbz-azetidine-3-carboxylic acid (CAS: 97628-92-7)?

1-Cbz-azetidine-3-carboxylic acid is a white crystalline solid with a molecular weight of 249.28 g/mol. It is sparingly soluble in water but soluble in organic solvents. This compound exhibits moderate reactivity in ester and amide formation. It is stable under normal conditions but sensitive to strong bases and acids.

How is 1-Cbz-azetidine-3-carboxylic acid (CAS: 97628-92-7) typically synthesized?

1-Cbz-azetidine-3-carboxylic acid is often synthesized through amidification of 1-Cbz-azetidine-3-carboxylic anhydride with appropriate bases. The reaction typically proceeds with good yield and selectivity using stoichiometric amounts of base under reflux conditions. Common catalysts include triethylamine and pyridine.

What industries use 1-Cbz-azetidine-3-carboxylic acid (CAS: 97628-92-7)?

1-Cbz-azetidine-3-carboxylic acid is used in the pharmaceutical industry for the synthesis of various biologically active compounds. It is also utilized in polymer synthesis for developing functional polymers with specific properties. Additionally, it plays a role in sensor technology and semiconductor manufacturing due to its reactivity and chemical stability.

What precautions should be taken when handling 1-Cbz-azetidine-3-carboxylic acid (CAS: 97628-92-7)?

When handling 1-Cbz-azetidine-3-carboxylic acid, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of dust or vapor. Spills should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).