3-Bromo-8-chloro-1,5-naphthyridine

Basic Information

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CAS Number

97267-61-3

Molecular Formula

C8H4BrClN2

Molecular Weight

243.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CN=C2C=C(C=NC2=C1Cl)Br

InChI

InChI=1S/C8H4BrClN2/c9-5-3-7-8(12-4-5)6(10)1-2-11-7/h1-4H

InChIKey

SKKJMLNKELECHI-UHFFFAOYSA-N

LogP

3.0457

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

167

Synonyms & References

English

7-BROMO-4-CHLORO-1,5-NAPHTHYRIDINE
AKOS025146569
SCHEMBL1932691
1,5-Naphthyridine, 3-bromo-8-chloro-
SKKJMLNKELECHI-UHFFFAOYSA-N
3-BROMO-8-CHLORO-1,5-NAPHTHYRIDINE
AS-33695
DTXSID60541368
EN300-132847
AMY26112
97267-61-3
MFCD11848377
SY042378
CS-0051446
PB26720
7-BroMo-4-chloro-1,5-naph...
Z1269199435
XDA26761
3-bromo-8-chloro-1,5-naphthyridine
3-Bromo-8-chloro-[1,5]naphthyridine
7-Bromo-4-chloro-1,5-naphthyridine
AB0198202

MDL Number

MFCD11848377

FAQ

What are the physical and chemical properties of 3-Bromo-8-chloro-1,5-naphthyridine (CAS: 97267-61-3)?

3-Bromo-8-chloro-1,5-naphthyridine is a crystalline solid with a molecular weight of approximately 299.03 g/mol. It has limited solubility in water but is soluble in common organic solvents like DMF and DMSO. This compound is known for its reactivity, particularly towards nucleophiles. It is moderately stable under normal storage conditions but should be protected from moisture and light.

How is 3-Bromo-8-chloro-1,5-naphthyridine (CAS: 97267-61-3) typically synthesized?

3-Bromo-8-chloro-1,5-naphthyridine is commonly synthesized via electrophilic aromatic substitution reactions. The synthesis often involves the bromination of 8-chloro-1,5-naphthyridine or its bromination followed by chlorination steps. The reaction is typically catalyzed by Lewis acids and proceeds with good yield and selectivity.

What industries use 3-Bromo-8-chloro-1,5-naphthyridine (CAS: 97267-61-3)?

3-Bromo-8-chloro-1,5-naphthyridine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of medicinal compounds. It also finds applications in the polymer industry for developing functional polymers, sensors, and semiconductors. Its unique chemical properties make it valuable in these sectors.

What precautions should be taken when handling 3-Bromo-8-chloro-1,5-naphthyridine (CAS: 97267-61-3)?

When handling 3-Bromo-8-chloro-1,5-naphthyridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for specific handling and disposal guidelines.