3-Bromo-8-chloro-1,5-naphthyridine(CAS: 97267-61-3)

3-Bromo-8-chloro-1,5-naphthyridine is a crystalline solid with a molecular weight of approximately 299.03 g/mol. It has limited solubility in water but is soluble in common organic solvents like DMF and DMSO. This compound is known for its reactivity, particularly towards nucleophiles. It is moderately stable under normal storage conditions but should be protected from moisture and light.

3-Bromo-8-chloro-1,5-naphthyridine is commonly synthesized via electrophilic aromatic substitution reactions. The synthesis often involves the bromination of 8-chloro-1,5-naphthyridine or its bromination followed by chlorination steps. The reaction is typically catalyzed by Lewis acids and proceeds with good yield and selectivity.

3-Bromo-8-chloro-1,5-naphthyridine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of medicinal compounds. It also finds applications in the polymer industry for developing functional polymers, sensors, and semiconductors. Its unique chemical properties make it valuable in these sectors.

When handling 3-Bromo-8-chloro-1,5-naphthyridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for specific handling and disposal guidelines.