Piroxicam-beta-cyclodextrin

Basic Information

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CAS Number

96684-39-8

Molecular Formula

C57H83N3O39S

Molecular Weight

1466.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

1541.2°Cat760mmHg

Flash Point

885.9°C

SMILES

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CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O

InChI

InChI=1S/C42H70O35.C15H13N3O4S/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h8-63H,1-7H2;2-9,19H,1H3,(H,16,17,20)

InChIKey

LBPBSKKEZXLVBQ-UHFFFAOYSA-N

LogP

-13.649600000000037

Topological Polar Surface Area

653.6500000000003 Å²

Hydrogen Bond Donor/Acceptor

23 / 42

Complexity

2090

Synonyms & References

English

beta-Cyclodextrin, compd. with 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxa...
beta-Cyclodextrin, compd. with 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Piroxicam-Beta-cyclodextrin
PIROXICAM-BETA-CYCLODEXTRIN, PHARMACEUTICAL GRADE
Cycladol
2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv. (ZCI)
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide, compd. with β-cyclodextrin (9CI)
CHF 1194
Piroxicam-β-cyclodextrin complex
Piroxicambeta-Cyclodextrin
DTXCID60164879
DTXSID60242388
Chf 1194
Chf-1194
Piroxicam-
96684-39-8
SCHEMBL1649802
SCHEMBL123958
Piroxicam-beta-cyclodextrin
121696-62-6
A-Cyclodextrin(x:1)

MDL Number

MFCD09952585

FAQ

What are the physical and chemical properties of Piroxicam-beta-cyclodextrin (CAS: 96684-39-8)?

Piroxicam-beta-cyclodextrin is a solid crystalline compound with a molecular weight of approximately 1367.5 g/mol. It has a low solubility in water but good solubility in organic solvents. The compound is relatively chemically stable but can undergo hydrolysis under acidic conditions. It forms a stable inclusion complex with beta-cyclodextrin, enhancing the solubility and stability of piroxicam.

How is Piroxicam-beta-cyclodextrin (CAS: 96684-39-8) typically synthesized?

Piroxicam-beta-cyclodextrin is synthesized by complexation of piroxicam with beta-cyclodextrin under mild conditions. This process involves dissolving piroxicam and beta-cyclodextrin in a suitable solvent, such as ethanol or acetone, and stirring until the complex forms. The mixture is then filtered, and the complex is dried to obtain the desired product.

What industries use Piroxicam-beta-cyclodextrin (CAS: 96684-39-8)?

Piroxicam-beta-cyclodextrin is primarily used in the pharmaceutical industry to improve the solubility and stability of piroxicam, a nonsteroidal anti-inflammatory drug (NSAID). It is also explored in polymer science for its potential to enhance the properties of polymers and in sensor technology due to its inclusion complex properties.

What precautions should be taken when handling Piroxicam-beta-cyclodextrin (CAS: 96684-39-8)?

When handling Piroxicam-beta-cyclodextrin, wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation of dust or vapors. Ensure proper storage and disposal according to the Safety Data Sheet (SDS). In case of spill, immediately clean up using appropriate methods and consult the SDS for further guidance.