Piroxicam-beta-cyclodextrin(CAS: 96684-39-8)

Piroxicam-beta-cyclodextrin is a solid crystalline compound with a molecular weight of approximately 1367.5 g/mol. It has a low solubility in water but good solubility in organic solvents. The compound is relatively chemically stable but can undergo hydrolysis under acidic conditions. It forms a stable inclusion complex with beta-cyclodextrin, enhancing the solubility and stability of piroxicam.

Piroxicam-beta-cyclodextrin is synthesized by complexation of piroxicam with beta-cyclodextrin under mild conditions. This process involves dissolving piroxicam and beta-cyclodextrin in a suitable solvent, such as ethanol or acetone, and stirring until the complex forms. The mixture is then filtered, and the complex is dried to obtain the desired product.

Piroxicam-beta-cyclodextrin is primarily used in the pharmaceutical industry to improve the solubility and stability of piroxicam, a nonsteroidal anti-inflammatory drug (NSAID). It is also explored in polymer science for its potential to enhance the properties of polymers and in sensor technology due to its inclusion complex properties.

When handling Piroxicam-beta-cyclodextrin, wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation of dust or vapors. Ensure proper storage and disposal according to the Safety Data Sheet (SDS). In case of spill, immediately clean up using appropriate methods and consult the SDS for further guidance.