4-Fluoro-2-methoxypyridine

Basic Information

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CAS Number

96530-81-3

Molecular Formula

C6H6FNO

Molecular Weight

127.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Density

1.1

Refractive Index

1.47

SMILES

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COC1=NC=CC(=C1)F

InChI

InChI=1S/C6H6FNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3

InChIKey

RGWFJFBUHTUVMV-UHFFFAOYSA-N

LogP

1.2293

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

89.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-Fluoro-2-methoxypyridine
2-METHOXY-4-FLUOROPYRIDINE
fluoromethoxypyridine
NSC 361062
PYRIDINE, 4-FLUORO-2-METHOXY-
4-fluoro-2-methoxy-pyridine
NSC361062
PubChem6596
4-fluoranyl-2-methoxy-pyridine
FCH855243
VP12345
AB53299
PC200266
AX8149718
AB0020655
V1620
530F813
A845605
J-
4-Fluoro-2-methoxypyridine (ACI)
2-Methoxy-4-fluoropyridine
NSC-361062
J-515341
EN300-121454
AKOS006284575
DB-027594
DTXSID70320545
CS-W006596
SY107590
MFCD09835267
96530-81-3

MDL Number

MFCD09835267

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Fluoro-2-methoxypyridine (CAS: 96530-81-3)?

4-Fluoro-2-methoxypyridine is a crystalline compound with a molecular weight of approximately 165.07 g/mol. It has a melting point of 82-85°C and a solubility of 2.4 g/L in water. This compound is moderately reactive, particularly with bases and reducing agents. It is insoluble in water but soluble in organic solvents such as ethanol and acetone.

How is 4-Fluoro-2-methoxypyridine (CAS: 96530-81-3) typically synthesized?

4-Fluoro-2-methoxypyridine is typically synthesized through the reaction of 2-methoxypyridine with hydrofluoric acid. This process involves the introduction of a fluorine atom at the 4-position of the pyridine ring. The yield is generally around 75-80%, and the reaction is performed under anhydrous conditions to avoid hydrolysis.

What industries use 4-Fluoro-2-methoxypyridine (CAS: 96530-81-3)?

4-Fluoro-2-methoxypyridine is primarily used in the pharmaceutical industry due to its potential as a precursor in the synthesis of various drugs. It is also utilized in the chemical industry for its reactivity in organic synthesis. Additionally, it has applications in the production of certain polymers and as a functional group in sensor and semiconductor manufacturing.

What precautions should be taken when handling 4-Fluoro-2-methoxypyridine (CAS: 96530-81-3)?

When handling 4-Fluoro-2-methoxypyridine, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be managed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be absorbed with dry sand or another inert material and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and disposal information.