4-Fluoro-2-methoxypyridine(CAS: 96530-81-3)

4-Fluoro-2-methoxypyridine is a crystalline compound with a molecular weight of approximately 165.07 g/mol. It has a melting point of 82-85°C and a solubility of 2.4 g/L in water. This compound is moderately reactive, particularly with bases and reducing agents. It is insoluble in water but soluble in organic solvents such as ethanol and acetone.

4-Fluoro-2-methoxypyridine is typically synthesized through the reaction of 2-methoxypyridine with hydrofluoric acid. This process involves the introduction of a fluorine atom at the 4-position of the pyridine ring. The yield is generally around 75-80%, and the reaction is performed under anhydrous conditions to avoid hydrolysis.

4-Fluoro-2-methoxypyridine is primarily used in the pharmaceutical industry due to its potential as a precursor in the synthesis of various drugs. It is also utilized in the chemical industry for its reactivity in organic synthesis. Additionally, it has applications in the production of certain polymers and as a functional group in sensor and semiconductor manufacturing.

When handling 4-Fluoro-2-methoxypyridine, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be managed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be absorbed with dry sand or another inert material and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and disposal information.