4-Amino-5-methylpyridin-2-ol

Basic Information

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CAS Number

95306-64-2

Molecular Formula

C6H8N2O

Molecular Weight

124.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

291.0±33.0 ºC (760 Torr),

Density

1.137±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

129.8±25.4 ºC,

SMILES

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CC1=CNC(=O)C=C1N

InChI

InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)

InChIKey

SSQZBQXJYGNUSC-UHFFFAOYSA-N

LogP

0.2655199999999999

Topological Polar Surface Area

58.879999999999995 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

203

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-amino-5-methyl-2(1H)-Pyridinone
4-Amino-5-methylpyridin-2-ol
4-Amino-5-methylpyridin-2(1H)-one
4-Amino-2-hydroxy-5-methylpyridine
4-amino-5-methyl-1H-pyridin-2-one
2(1H)-Pyridinone, 4-amino-5-methyl-
4-amino-5-methyl-2-pyridone
SSQZBQXJYGNUSC-UHFFFAOYSA-N
4-Amino-5-methylpyridine-2(1H)-one
AK128273
ST2405541
4-Amino-5-methyl-2(1H)-pyridinone (ACI)
2-Hydroxy-4-amino-5-methylpyridine
4-Amino-5-methyl-1H-pyridin-2-one
4-amino-5-methyl-2(1H)-pyridinone
SCHEMBL18799988
NS00004169
CS-W022074
4-amino-5-methylpyridone
MFCD12546373
SCHEMBL2460386
EC 682-818-3
AC-30730
EN300-1294933
F14705
AKOS006337543
DTXSID00535408
4-amino-5-methylpyridin-2(1H)-one
4-AMINO-5-METHYL-1H-PYRIDIN-2-ONE
SY020547
95306-64-2

MDL Number

MFCD12546373

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Amino-5-methylpyridin-2-ol (CAS: 95306-64-2)?

4-Amino-5-methylpyridin-2-ol is a crystalline solid with a molecular weight of approximately 150.19 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetone. The compound shows moderate reactivity towards electrophiles and nucleophiles, making it suitable for various synthetic transformations. It has a melting point of around 160-162°C.

How is 4-Amino-5-methylpyridin-2-ol (CAS: 95306-64-2) typically synthesized?

4-Amino-5-methylpyridin-2-ol can be synthesized through the reaction of 5-methylpyridine with ammonia in the presence of a suitable catalyst, such as Raney nickel or a transition metal complex. The reaction is typically carried out under pressure and at elevated temperatures. The yield and selectivity can be enhanced by optimizing reaction conditions and using appropriate catalysts.

What industries use 4-Amino-5-methylpyridin-2-ol (CAS: 95306-64-2)?

4-Amino-5-methylpyridin-2-ol is used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It also finds applications in the polymer industry for the synthesis of functionalized polymers. Additionally, it can be used in the production of sensors and as a reagent in organic synthesis due to its functional groups.

What precautions should be taken when handling 4-Amino-5-methylpyridin-2-ol (CAS: 95306-64-2)?

When handling 4-Amino-5-methylpyridin-2-ol, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.