4-Amino-5-methylpyridin-2-ol(CAS: 95306-64-2)

4-Amino-5-methylpyridin-2-ol is a crystalline solid with a molecular weight of approximately 150.19 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetone. The compound shows moderate reactivity towards electrophiles and nucleophiles, making it suitable for various synthetic transformations. It has a melting point of around 160-162°C.

4-Amino-5-methylpyridin-2-ol can be synthesized through the reaction of 5-methylpyridine with ammonia in the presence of a suitable catalyst, such as Raney nickel or a transition metal complex. The reaction is typically carried out under pressure and at elevated temperatures. The yield and selectivity can be enhanced by optimizing reaction conditions and using appropriate catalysts.

4-Amino-5-methylpyridin-2-ol is used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It also finds applications in the polymer industry for the synthesis of functionalized polymers. Additionally, it can be used in the production of sensors and as a reagent in organic synthesis due to its functional groups.

When handling 4-Amino-5-methylpyridin-2-ol, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.