(4-Fluoro-4-piperidinyl)methanol

Basic Information

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CAS Number

949100-11-2

Molecular Formula

C6H12FNO

Molecular Weight

133.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

202 ºC

Density

1.10

Flash Point

76 ºC

SMILES

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C1CNCCC1(CO)F

InChI

InChI=1S/C6H12FNO/c7-6(5-9)1-3-8-4-2-6/h8-9H,1-5H2

InChIKey

HMCPBCNFXXRANL-UHFFFAOYSA-N

LogP

0.07039999999999985

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

91.1

Synonyms & References

English

AKOS006380383
CS-0102304
4-FLUORO-4-PIPERIDINEMETHANOL
(4-FLUOROPIPERIDIN-4-YL)METHANOL
AS-53762
PB28680
4-Fluoropiperidine-4-methanol
FT-0727490
SCHEMBL670786
EN300-112763
4-FLUORO-4-(HYDROXYMETHYL)PIPERIDINE
949100-11-2
P17075
DTXSID801307235
(4-Fluoropiperidin-4-yl)methanol
4-fluoro-4-Piperidinemethanol
(4-fluoro-4-piperidyl)methanol
(4-Fluoro-piperidin-4-yl)-methanol

MDL Number

MFCD17016038

FAQ

What are the physical and chemical properties of (4-Fluoro-4-piperidinyl)methanol (CAS: 949100-11-2)?

(4-Fluoro-4-piperidinyl)methanol is a colorless or white crystalline solid with a molecular weight of approximately 164.15 g/mol. It is slightly soluble in water but soluble in organic solvents like dimethylformamide (DMF). This compound exhibits moderate reactivity, particularly towards nucleophiles and acid catalysis. It is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

How is (4-Fluoro-4-piperidinyl)methanol (CAS: 949100-11-2) typically synthesized?

(4-Fluoro-4-piperidinyl)methanol can be synthesized via the reduction of 4-fluoro-4-piperidone using sodium borohydride in a suitable solvent such as ethanol. The reaction typically proceeds with 90% yield and good selectivity, making it a reliable method for industrial synthesis.

What industries use (4-Fluoro-4-piperidinyl)methanol (CAS: 949100-11-2)?

(4-Fluoro-4-piperidinyl)methanol finds applications in the pharmaceutical industry as an intermediate for synthesizing various bioactive compounds. It is also used in the polymer industry for modifying the properties of polymers to enhance their performance in specific applications. Additionally, it may be used in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling (4-Fluoro-4-piperidinyl)methanol (CAS: 949100-11-2)?

When handling (4-Fluoro-4-piperidinyl)methanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be carefully cleaned up using appropriate absorbents, and used materials should be disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.