5-bromo-4-fluoro-pyridin-2-amine

Basic Information

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CAS Number

944401-69-8

Molecular Formula

C5H4BrFN2

Molecular Weight

191 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

233.6±35.0 ºC (760 Torr),

Density

1.813±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

95.1±25.9 ºC,

SMILES

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C1=C(C(=CN=C1N)Br)F

InChI

InChI=1S/C5H4BrFN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9)

InChIKey

GGHBRLQYBZMEPV-UHFFFAOYSA-N

LogP

1.5654

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

101

Synonyms & References

English

AMY6283
MFCD16658678
A859422
AKOS016002753
5-Bromo-4-fluoro-2-pyridinamine
GGHBRLQYBZMEPV-UHFFFAOYSA-N
Z1255367303
2-Amino-5-bromo-4-fluoropyridine
DS-3532
944401-69-8
SCHEMBL1257119
CS-W019689
SB18620
EN300-197329
5-Bromo-4-fluoropyridin-2-amine
DTXSID40728291
SY034433
C5H4BrFN2
5-Bromo-4-fluoro-2-pyridinamine (ACI)
2-Amino-4-fluoro-5-bromopyridine
5-bromo-4-fluoro-pyridin-2-amine

MDL Number

MFCD16658678

FAQ

What are the physical and chemical properties of 5-bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8)?

5-Bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8) is a solid with a crystalline form. It has a molecular weight of approximately 240.03 g/mol. This compound is moderately soluble in water and soluble in organic solvents like dichloromethane and ethanol. It is slightly reactive, showing basic properties due to the amine group. It can be used in various synthetic reactions, typically requiring mild to moderate conditions.

How is 5-bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8) typically synthesized?

5-Bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8) is often synthesized through a multi-step process involving the bromination of 4-fluoropyridine followed by an amination step. The synthesis typically requires the use of a brominating agent, such as N-bromosuccinimide (NBS), and a suitable amine. The process yields a high purity product with good selectivity. The overall yield is generally around 70-80%.

What industries use 5-bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8)?

5-Bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8) is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the development of new drugs and as an intermediate in the synthesis of various chemical compounds. Its properties make it useful in the production of polymers, sensors, and semiconductors, although its application in these areas is less common compared to pharmaceuticals.

What precautions should be taken when handling 5-bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8)?

When handling 5-bromo-4-fluoro-pyridin-2-amine (CAS: 944401-69-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure to the potentially harmful vapor. Spills should be handled with caution, using appropriate cleanup procedures and ensuring that all waste is disposed of in compliance with local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.