(2E)-3-(4-Methoxyphenyl)acrylic acid

Basic Information

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CAS Number

943-89-5

Molecular Formula

C10H10O3

Molecular Weight

178.19 g/mol

Basic Physical Properties

Melting Point

173.5 °C

Boiling Point

342.6 °C at 760 mmHg

Density

1.195

Flash Point

138.5 °C

Solubility

Soluble in ethanol, ethyl acetate and other organic solvents.

SMILES

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COc1ccc(/C=C/C(=O)O)cc1

InChI

InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+

InChIKey

AFDXODALSZRGIH-QPJJXVBHSA-N

LogP

1.7930000000000001

Topological Polar Surface Area

46.53 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

190

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-methoxycinnamic acid
(E)-3-(4-Methoxyphenyl)-2-propenoic acid
(E)-4-Methoxycinnamic Acid
trans-4-Methoxycinnamic acid
3-(4-Methoxy-phenyl)-acrylic acid
trans-O-Methyl-p-coumaric Acid
3-(4-Methoxyphenyl)acrylic acid
P-METHOXYCINNAMIC ACID
(E)-3-(4-Methoxyphenyl)acrylic acid
4-Methoxycinnamate
para-methoxycinnamic acid
O-Methyl-p-coumaric acid
Cinnamic acid, p-methoxy-
(E)-3-(4-methoxyphenyl)prop-2-enoic acid
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
2-Propenoic acid, 3-(4-methoxyphenyl)-
2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-
3-(4-Methoxyphenyl)-2-propenoic acid
Cinnamic ac
(2E)-3-(4-Methoxyphenyl)-2-propenoic acid (ACI)
2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)- (ZCI)
Cinnamic acid, p-methoxy-, (E)- (8CI)
(E)-4-Methoxycinnamic acid
(E)-p-Methoxycinnamic acid
trans-3-(4-Methoxyphenyl)-2-propenoic acid
trans-p-Methoxycinnamic acid

MDL Number

MFCD00004398

Customs Code

2916399090

FAQ

What are the physical and chemical properties of (2E)-3-(4-Methoxyphenyl)acrylic acid (CAS: 943-89-5)?

(2E)-3-(4-Methoxyphenyl)acrylic acid is a colorless solid with a molecular weight of approximately 198.17 g/mol. It has a pKa of about 3.5 and is slightly soluble in water. It is chemically reactive, particularly towards nucleophiles and bases, and can undergo polymerization under certain conditions.

How is (2E)-3-(4-Methoxyphenyl)acrylic acid (CAS: 943-89-5) typically synthesized?

(2E)-3-(4-Methoxyphenyl)acrylic acid can be synthesized by reacting 4-methoxybenzaldehyde with acrylic anhydride in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction typically proceeds with good yield and selectivity, though careful control of reaction conditions is necessary to avoid side products.

What industries use (2E)-3-(4-Methoxyphenyl)acrylic acid (CAS: 943-89-5)?

(2E)-3-(4-Methoxyphenyl)acrylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry as a monomer for polymerization processes, and in the sensor industry for the development of chemical sensors. It is also used in the semiconductor industry for specific applications.

What precautions should be taken when handling (2E)-3-(4-Methoxyphenyl)acrylic acid (CAS: 943-89-5)?

PPE required when handling (2E)-3-(4-Methoxyphenyl)acrylic acid includes gloves, goggles, and a lab coat. The substance should be handled in a fume hood. Spills should be carefully cleaned up using absorbent materials, and the area should be well ventilated. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.