Fluvastatin methyl ester

Basic Information

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CAS Number

93957-53-0

Molecular Formula

C25H28FNO4

Molecular Weight

425.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)OC)O)O)C3=CC=C(C=C3)F

InChI

InChI=1S/C25H28FNO4/c1-16(2)27-22-7-5-4-6-21(22)25(17-8-10-18(26)11-9-17)23(27)13-12-19(28)14-20(29)15-24(30)31-3/h4-13,16,19-20,28-29H,14-15H2,1-3H3/b13-12+/t19-,20-/m0/s1

InChIKey

BOCZYIUKFAQNLG-DSJWGCTQSA-N

LogP

4.716500000000007

Topological Polar Surface Area

71.69 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

604

Synonyms & References

English

(3S,5R,E)-Methyl 7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoate
luvastatin methyl ester
methyl (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate
Fluvastatin F-4
Fluvastatin Methyl Ester
(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic Acid Methyl Ester
[R*,S*-(E)]-(+/-)-7-[3-(4-Fluorophenyl)-1-(1-Methylethyl) -1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic Acid Methyl Ester
methyl erythro-(E)-3,5-dihydroxy-7-[3-(4-fluorophenyl)-1-(1-methylethyl)indol-2-yl]hept-6-enoate
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, methyl ester, [R*,S*-(E)]-(±)- (ZCI)
rel-Methyl (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoate (ACI)
(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid methyl ester
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, methyl ester, [R*,S*-(E)]-
methyl (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
DTXSID201111963
93957-53-0
Fluvastatin methyl ester
Methyl(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoate
(3S,5R,E)-Methyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoate
rel-Methyl (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoate
BOCZYIUKFAQNLG-DSJWGCTQSA-N
SCHEMBL557533
GLXC-15134
J-521374
AKOS016843746

MDL Number

MFCD08458340

FAQ

What are the physical and chemical properties of Fluvastatin methyl ester (CAS: 93957-53-0)?

Fluvastatin methyl ester (CAS: 93957-53-0) is a white to off-white crystalline powder with a molecular weight of approximately 338.4 g/mol. It has a low water solubility and is soluble in organic solvents like methanol and ethanol. This compound is relatively stable but can react with strong bases and is prone to hydrolysis under basic conditions. It is used in the synthesis of statins and has potential applications in pharmaceuticals.

How is Fluvastatin methyl ester (CAS: 93957-53-0) typically synthesized?

Fluvastatin methyl ester (CAS: 93957-53-0) is typically synthesized through a multi-step process involving the protection of the hydroxyl group of mevastatin, followed by esterification with methanol. This process requires careful control of pH and temperature to ensure high selectivity and yield. The use of appropriate catalysts and solvents is crucial for achieving the desired product.

What industries use Fluvastatin methyl ester (CAS: 93957-53-0)?

Fluvastatin methyl ester (CAS: 93957-53-0) is primarily used in the pharmaceutical industry for the production of statins. It is also used in the research and development of cholesterol-lowering drugs. Additionally, due to its structural similarity to other statins, it may have applications in the polymer and sensor industries.

What precautions should be taken when handling Fluvastatin methyl ester (CAS: 93957-53-0)?

When handling Fluvastatin methyl ester (CAS: 93957-53-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves and goggles, to prevent skin and eye contact. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, use appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.